| Autor: |
I. Zimmermann, R. Saedler, M. Mutondo, M. Hulskamp |
| Předmět: |
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| Zdroj: |
Molecular Genetics & Genomics; Oct2004, Vol. 272 Issue 3, p290-296, 55p |
| Abstrakt: |
In plants many aspects of cell shape regulation are controlled by actin-dependent processes. The ARP2/3 complex has been recognized as a regulator of actin organization. Mutations in genes encoding components of the ARP2/3 complex lead to cell shape defects in several cell types, including trichomes, epidermal pavement cells and hypocotyl cells. We show here that mutations in the GNARLED ( GRL) gene cause a similar range of phenotypes. The GRL gene encodes the Arabidopsis homolog of NAP125, which in animals is known to act as one regulator of the ARP2/3-regulating complex WAVE-HSPC300. As an HSPC300 homolog is present in the Arabidopsis genome but no WAVE homolog has yet been found, the existence of a related regulation pathway was doubtful. Our finding that GRL encodes a putative regulator of the WAVE-HSPC300 complex, NAP125, combined with the phenotypic similarity between arp2/3 and grl mutants, provides evidence that the ARP2/3 complex is indeed regulated by the above mentioned pathway in Arabidopsis. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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