The Influence of Pantogam and Atomoxetine on Attention Stability and Distribution of Dopamine D2 and GABAB Receptors in the Attention Deficit Mouse Model.

Autor: Kovalev, G. I., Sukhorukova, N. A., Vasileva, E. V., Kondrakhin, E. A., Salimov, R. M.
Zdroj: Biochemistry (Biokhimiya). Supplemental Series B, Biomedical Chemistry; Mar2022, Vol. 16 Issue 1, p30-37, 8p
Abstrakt: The closed enriched cross maze test was employed as a novel experimental model of the attention deficit disorder (ADD) for evaluation of the behavioral and neurochemical effects of the nootropic drug pantogam (100 mg/kg, intraperitoneally) and atomoxetine hydrochloride (3 mg/kg, intraperitoneally) administered subchronically to CD-1 outbred mice. Two subpopulations of rodents spontaneously diverging in attention to enriched compartments (ED-Low and ED-High), were estimated on the basis of time spent by the mice in the empty or enriched compartments. The ED-Low and ED-High mice did not differ in parameters associated with anxiety, exploratory efficacy, and locomotor activity. Subchronic administration of both drugs in selected doses produced a corrective effect on animal behavior manifested as selective increase in the ED-ratio values in the ED-Low subpopulation (p < 0.05). The radioligand binding assays revealed differences in the distribution of dopamine D2 and GABAB receptors (Bmax) in prefrontal cortex of control ED-Low and ED-High mice. In prefrontal cortex of ED-Low mice treatment with atomoxetine produced a decrease in the Bmax values of D2 receptors by 14%, while pantogam decreased the Bmax values of D2 receptors by 22% (p < 0.05) and increased the Bmax values for GABAB receptor binding by 44%. Thus, subchronic administration of pantogam had a selective corrective effect on the behavior parameters and the density of the studied receptor subtypes in animals having had severe attention deficit in the test. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
Externí odkaz: