Identification of a novel therapeutic target in vascular dysfunction: a showcase of reverse and forward translational research linking bench to bedside.

Autor: Iwata, Hiroshi, Minamino, Tohru
Předmět:
Zdroj: European Heart Journal; 2/7/2022, Vol. 43 Issue 6, p501-503, 3p
Abstrakt: An editorial is presented on tubulin-folding cofactor E deficiency promoting vascular dysfunction by increasing endoplasmic reticulum stress. Topics include pathological vascular remodelling leading to vascular malfunction, neointima thickening, and atherosclerosis; and releasing cytokines and proteases provoking further inflammation and tissue remodelling.
Databáze: Complementary Index