Synthesis and molecular structure of 4-{[6-((2SR,4SR)-4-acetyl-4-methylpyrrolidin-2-yl)-2-(4-cyanophenoxy)pyrimidin-4-yl]oxy}-3,5-dimethylbenzonitrile and 4-[(6-{(2SR,4SR)-4-acetyl-1-[(4-bromophenyl)sulfonyl]-4-methylpyrrolidin-2-yl}-2-(4-cyanophenoxy)pyrimidin-4-yl)oxy]-3,5-dimethylbenzonitrile

Autor: Sokolov, Nikita А., Ivanov, Vladimir N., Iusupov, Ildar R., Iasevich, Anton V., Trubnikov, Artem V., Ulianova, Yuliya V., Lyssenko, Konstantin А., Kurkin, Alexander V.
Předmět:
Zdroj: Chemistry of Heterocyclic Compounds; Jan2022, Vol. 58 Issue 1, p64-67, 4p
Abstrakt: A novel diarylpyrimidine derivative, 4-{[6-((2SR,4SR)-4-acetyl-4-methylpyrrolidin-2-yl)-2-(4-cyanophenoxy)pyrimidin-4-yl]oxy}- 3,5-dimethylbenzonitrile containing a pyrrolidine moiety at position 6 of the pyrimidine ring was obtained as a result of the tandem aza- Cope/Mannich reaction between 4-{[2-(4-cyanophenoxy)-6-formylpyrimidin-4-yl]oxy}-3,5-dimethylbenzonitrile and 1-amino- 2,3-dimethylbut-3-en-2-ol in methylene chloride in the presence of 10-camphorsulfonic acid. The structure of the product of its reaction with 4-bromobenzenesulfonyl chloride, 4-[(6-{(2SR,4SR)-4-acetyl-1-[(4-bromophenyl)sulfonyl]-4-methylpyrrolidin-2-yl}-2-(4-cyanophenoxy) pyrimidin-4-yl)oxy]-3,5-dimethylbenzonitrile, was investigated by X-ray structural analysis. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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