Detection of a second primary cancer in a 18F-fluorocholine PET/CT - multicentre retrospective analysis on a group of 1345 prostate cancer patients.
| Autor: | Cegla, Paulina, Scibisz-Dziedzic, Katarzyna, Witkowska, Kamila, Kubiak, Anna, Wierzchoslawska, Ewa, Kycler, Witold, Chrapko, Beata, Czepczynski, Rafal |
|---|---|
| Předmět: |
RESEARCH
REPORTING of diseases MESOTHELIOMA BLADDER tumors HEAD tumors RETROSPECTIVE studies MEDICAL cooperation LUNG tumors CANCER patients COLORECTAL cancer SKIN tumors SECONDARY primary cancer RADIOPHARMACEUTICALS HEMATOLOGIC malignancies TESTIS tumors KIDNEY tumors DESCRIPTIVE statistics COMPUTED tomography PROSTATE tumors ESOPHAGEAL tumors SQUAMOUS cell carcinoma NECK tumors |
| Zdroj: | Nuclear Medicine Review; 2022, Vol. 25 Issue 1, p25-30, 6p |
| Abstrakt: | Background: Aim of this study was to evaluate the rate of incidental detection of second primary cancer (SPC) at 18F-fluorocholine ([18F]FCH) positron emission tomography/computed tomography (PET/CT) performed in prostate cancer patients. Material and methods: A retrospective analysis was performed on a group of 1345 prostate cancer patients, who underwent [18F]FCH PET/CT study because of suspicion of recurrence (n = 937) or for initial staging (n = 408). Images were acquired after intravenous injection [18F]FCH with a mean activity of 200 ± 75 MBq (5.4 ± 2 mCi), from the top of the head to the half of the thigh. The confirmation of second primary cancer was obtained from the cancer registry. Results: Based on the [18F]FCH PET/CT scans, a second primary cancer was suspected in 89 patients (6.6%). Of these, a malignancy was histologically confirmed in 26 patients (29% of all suspected findings and 1.9% of the complete cohort). Lung cancer (including adenocarcinoma, neuroendocrine cancer) was diagnosed in 13 patients (50%) and hematologic neoplasm (including chronic lymphocytic leukemia, Hodgkin lymphoma, follicular lymphoma, and multiple myeloma) in 5 patients (19%). 18F-fluorocholine PET/CT also revealed esophageal cancer, mesothelioma, testicular, renal, bladder, and colorectal cancer in individual patients, non-keratinizing squamous cell carcinoma (SCC) of the skin as well as head and neck SCC with unknown primary. Conclusion: We conclude that incidental detection of a second primary cancer in prostate cancer patients using [18F]FCH PET/CT is not very common and that lung cancer and hematologic malignancies are most frequently detected. [ABSTRACT FROM AUTHOR] |
| Databáze: | Complementary Index |
| Externí odkaz: |
|