Photoredox catalyzed cascade CF3 addition/chemodivergent annulations of ortho-alkenyl aryl ureas.

Autor: Babu, Sakamuri Sarath, Varma, A Anagha, Gopinath, Purushothaman
Předmět:
Zdroj: Chemical Communications; 2/11/2022, Vol. 58 Issue 12, p1990-1993, 4p
Abstrakt: Herein, we report a substrate-controlled cascade cyclization of o-alkenyl aryl ureas, an ambident nucleophile for constructing functionalized heterocycles such as 2-amino-1,3-benzoxazines and dihydroquinazolinones in a chemodivergent fashion using photoredox catalysis under mild conditions. The versatility of the method has been successfully demonstrated by applying this strategy to a wide range of substrates and for the synthesis of functionalized etifoxine drug derivatives. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index