Self-Reported Sleep Quality Across Age Modulates Resting-State Functional Connectivity in Limbic and Fronto-Temporo-Parietal Networks: An Exploratory Cross-Sectional fMRI Study.
| Autor: | Federico, Giovanni, Alfano, Vincenzo, Garramone, Federica, Mele, Giulia, Salvatore, Marco, Aiello, Marco, Cavaliere, Carlo |
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| Předmět: |
FUNCTIONAL connectivity
SLEEP interruptions CROSS-sectional method SLEEP COGNITIVE ability SHORT-term memory RESEARCH MEMORY LIMBIC system THREE-dimensional imaging SELF-evaluation LARGE-scale brain networks COGNITION REGRESSION analysis QUESTIONNAIRES MENTAL depression DESCRIPTIVE statistics RESEARCH funding ANXIETY STATISTICAL sampling |
| Zdroj: | Frontiers in Aging Neuroscience; 2/7/2022, Vol. 14, p1-9, 9p |
| Abstrakt: | Sleep problems are increasingly present in the general population at any age, and they are frequently concurrent with—or predictive of—memory disturbances, anxiety, and depression. In this exploratory cross-sectional study, 54 healthy participants recruited in Naples (Italy; 23 females; mean age = 37.1 years, range = 20–68) completed the Pittsburgh Sleep Quality Index (PSQI) and a neurocognitive assessment concerning both verbal and visuospatial working memory as well as subjective measures of anxiety and depression. Then, 3T fMRI images with structural and resting-state functional sequences were acquired. A whole-brain seed-to-seed functional connectivity (FC) analysis was conducted by contrasting good (PSQI score <5) vs. bad (PSQI score ≥5) sleepers. Results highlighted FC differences in limbic and fronto-temporo-parietal brain areas. Also, bad sleepers showed an anxious/depressive behavioural phenotype and performed worse than good sleepers at visuospatial working-memory tasks. These findings may help to reveal the effects of sleep quality on daily-life cognitive functioning and further elucidate pathophysiological mechanisms of sleep disorders. [ABSTRACT FROM AUTHOR] |
| Databáze: | Complementary Index |
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