| Autor: |
Vigorov, A. Yu., Krasnov, V.P., Nizova, I. A., Sadretdinova, L. Sh., Matveeva, T. V., Slepukhin, P. A., Levit, G. L., Bakulin, D. A., Kovalyov, N. S., Tyurenkov, I. N. |
| Předmět: |
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| Zdroj: |
AIP Conference Proceedings; 2022, Vol. 2390 Issue 1, p1-7, 7p |
| Abstrakt: |
Starting from dimethyl (2S,4RS)-4-bromo-N-phthaloylglutamate, a series of (2S,4S)-4-amino-N-arylpyroglutamic acids has been obtained. It has been found that 4-amino-N-(4-bromophenyl) and 4-amino-N-(4-aminophenyl) pyroglutamic acids exhibit a pronounced anxiolytic effect in the Elevated plus maze and Vogel conflict tests in rats. 4-Amino-N-(4-methylphenyl), 4-amino-N-(4-bromophenyl), 4-amino-N-(4-aminophenyl), and 4-amino-N-(2,3-dimethyl-5-oxo-1-phenyl-3-pyrazolin-4-yl) pyroglutamic acids exhibited nootropic properties in the Passive avoidance and Extrapolation escape tests. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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