Synthesis of 7-formyl methyl abietate via Vilsmeier-Haack reaction and cytotoxic activity of abietane diterpene derivatives.

Autor: Tretyakova, E. V., Salimova, E. V., Parfenova, L. V.
Předmět:
Zdroj: AIP Conference Proceedings; 2022, Vol. 2390 Issue 1, p1-5, 5p
Abstrakt: Synthesis of methyl 7-formylabieta-7,13-dien-18-oate was achieved by formylation of the abietic acid methyl ester under Vilsmeier-Haack conditions. The in vitro cytotoxicity of the abietic and dehydroabietic acid derivatives against the NCI-60 cancer cell line panel was also studied. The dehydroabietic acid aminopropargyles showed promising antitumor activity against leukemia CCRF-CEM and RPMI-8226 cancer cell lines. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index