| Autor: |
Bondareva, N. A., Purygin, P. P., Ermokhin, V. A., Gilmutdinova, A. S., Bashirova, L. I. |
| Předmět: |
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| Zdroj: |
AIP Conference Proceedings; 2022, Vol. 2390 Issue 1, p1-5, 5p |
| Abstrakt: |
Various drugs are used in modern pharmaceuticals nowadays that affect the blood hemostasis processes. Their spectrum is quite wide and well-studied. Nevertheless, the question of the synthesis of new drugs acting on hemostasis with fewer side effects remains open. Thus, we chose aminocaproic acid for our work as this substance has a well-known property: the effect of inhibition of fibrinolysis. By means of blocking plasminogen activators and by partially inhibiting the action of plasmin, aminocaproic acid can have a specific hemostatic effect in the case of bleeding associated with increased fibrinolysis. Considering this information, aminocaproic acid was chosen for our research. We synthesized various compositions of compounds based on aminocaproic acid. Based on the above observations, we selected several organic compounds with various aggregate, antiaggregate and antiviral properties. In view of further using them in the synthesis of new organic compounds with a more complex molecular structure, we have obtained the following complex organic compounds of aminocaproic acid with taurine, lithium taurate, calcium taurate, lysine and aspirin. The resulting compounds were tested in an aggregometer using platelet-saturated human blood plasma to determine anti- or pro-aggregate activity. The compounds showed varying degrees of expression in the effect on platelet functional activity. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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