Making Sense of Phase II Trials for Investigational Agents in COVID-19: The Case of Ilomedin in Mechanically Ventilated Patients.

Autor: Zampieri, Fernando G., Ginde, Adit
Zdroj: American Journal of Respiratory & Critical Care Medicine; 2/1/2022, Vol. 205 Issue 3, p267-269, 3p
Abstrakt: The article presents the discussion on feasibility trials being underappreciated being an essential part of building a solid evidence-based practice. Topics include prostacyclin attenuating endotheliopathy mainly through local prostacyclin and platelet adhesion inhibition; and reporting the treatment effect in survivors leading to an overcounting of mortality across most of the endpoints.
Databáze: Complementary Index