| Autor: |
Hong, Feng‐Lin, Shi, Chong‐Yang, Hong, Pan, Zhai, Tong‐Yi, Zhu, Xin‐Qi, Lu, Xin, Ye, Long‐Wu |
| Předmět: |
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| Zdroj: |
Angewandte Chemie International Edition; 2/7/2022, Vol. 61 Issue 7, p1-8, 8p |
| Abstrakt: |
Here, we report a copper‐catalyzed asymmetric cascade cyclization/[1,2]‐Stevens‐type rearrangement via a non‐diazo approach, leading to the practical and atom‐economic assembly of various valuable chiral chromeno[3,4‐c]pyrroles bearing a quaternary carbon stereocenter in generally moderate to good yields with wide substrate scope and excellent enantioselectivities (up to 99 % ee). Importantly, this protocol not only represents the first example of catalytic asymmetric [1,2]‐Stevens‐type rearrangement based on alkynes but also constitutes the first asymmetric formal carbene insertion into the Si−O bond. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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