MACS-DGC versus DGC Sperm Wash Procedure: Comparing Clinical Outcomes in Couples with Male Factor Infertility Undergoing ICSI: A Clinical Trial Study.

Autor: Norozi-Hafshejani, Marziyeh, Tavalaee, Marziyeh, Najafi, Mohammad Hassan, Shapouri, Farnaz, Arbabian, Maryam, Nasr-Esfahani, Mohammad Hossein
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Zdroj: International Journal of Fertility & Sterility; Jan-Mar2022, Vol. 16 Issue 1, p17-22, 6p
Abstrakt: Background: Implementation of sperm preparation techniques based on cellular and molecular characteristics can improve the clinical outcomes of couples with male factor infertility. These methods attempt to select better sperm compared to classical methods of preparation such as swim-up and density gradient centrifugation (DGC). In this view, the aim of this study was the comparison of clinical outcomes of magnetic-activated cell separation (MACS) followed by DGC or DGC alone in infertile men undergoing intracytoplasmic sperm injection (ICSI). Materials and Methods: For this prospective single parallel blind clinical trial study, 206 infertile couples with male factor infertility and having abnormal sperm morphology higher than 96% were included. 106 and 100 couples were considered for the study (MACS-DGC) and control group (DGC), respectively. Clinical outcomes of ICSI; fertilization, embryo quality, and implantation, pregnancy rates were compared between two groups. Results: Mean of fertilization (80.19 ± 1.88 vs. 75.63 ± 2.06, P=0.1), top embryo quality on the day 3 (30.22 ± 3.59 vs. 17.96 ± 2.9, P=0.009), clinical pregnancy (30.76% vs. 22.22%, P=0.19), and implantation rate (18.12% vs. 10.42%, P=0.04) were higher in the study group compared to the control group. Conclusion: Sperm preparation by MACS followed by DGC in teratozoospermic men could improve the clinical out- comes after ICSI (Registration number: IRCT201610317223N8). [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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