| Autor: |
Kassapidou, Maria, Stenport, Victoria Franke, Johansson, Carina B., Östberg, Anna-Karin, Johansson, Petra Hammarström, Hjalmarsson, Lars |
| Předmět: |
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| Zdroj: |
Journal of Oral & Maxillofacial Research; Oct-Dec2021, Vol. 12 Issue 4, p1-11, 11p |
| Abstrakt: |
Objectives: To explore the in vitro cytokine expression of human peripheral blood mononuclear cells exposed to cobaltchromium alloys, manufactured with different techniques, in comparison with commercially pure titanium grade 4 and titanium alloy grade 23. Material and Methods: Peripheral blood mononuclear cells (PBMC) were collected from 10 healthy blood donors and exposed to machine-ground coin-shaped: (a) cobalt-chromium (Co-Cr) specimens (n = 5) manufactured by four techniques, i.e. cast, milled, laser melted and presintered milled; (b) commercially pure titanium grade 4; and (c) titanium alloy grade 23. The cells were cultured for 4, 24 and 72 hours followed by investigations of pro- and anti-inflammatory cytokine release using Bio-Plex Pro™. Results: In general, the PBMC produced significantly more cytokines when exposed to the cast and presintered milled Co-Cr materials compared to laser melted, milled Co-Cr and titanium materials. Conclusions: Within the limitation of the present study, it may be suggested that cast and presintered milled cobalt-chromium alloys provoke a stronger inflammatory response compared to milled and laser melted cobalt-chromium alloys and titanium materials. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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