| Autor: |
Şahin, Muammer Melih, Cayonu, Melih, Dinc, Secil Kayalı, Ozkocer, Esra, Ilhan, Mert, Uzunoğlu, Eray, Elmas, Cigdem, Yılmaz, Metin, Akkol, Esra |
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| Zdroj: |
European Archives of Oto-Rhino-Laryngology; Feb2022, Vol. 279 Issue 2, p987-994, 8p |
| Abstrakt: |
Purpose: There is still no widely-accepted local agent proven to be effective in nerve regeneration. We aimed to investigate the effects of chitosan gel and platelet-rich plasma Materials and methods: Electrophysiological measurements were performed before and immediately after injury. The injured nerves were covered with spongostan impregnated with the following agents: Group 1 (Control Group): Saline at a dose of 50 µl; Group 2: Chitosan (CHT) at a dose of 50 µl; Group 3: PRP at a dose of 50 ml; and Group 4: a solution of CHT with PRP (1:1). The final measurements were performed after 3 weeks and the injured nerve of each rat was removed. Results: There were statistically-significant differences between the groups regarding the measurements of the after-treatment values of stimulus threshold (p < 0.05). The best improvement in electrophysiological measurement and histopathological evaluation was found in Group 4 (CHT-PRP). Conclusion: Chitosan gel has a positive effect on nerve healing and applying it along with PRP can enhance the effect of chitosan. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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