| Autor: |
Davtyan, Tigran K., Hakobyan, Isabelle S., Manukyan, Hayk A., Avelisyan, Samvel A., Gabrielyan, Emil S. |
| Předmět: |
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| Zdroj: |
Electronic Journal of Natural Sciences; Jul2004, Vol. 3 Issue 2, p22-30, 9p |
| Abstrakt: |
Iodophores consist of elementary iodine bound to polymer carriers and serve as broad-spectrum microbicides. Here we show that lithium-containing iodophore (LCI) which consists of low molecular weight a-dextrin and polyvinyl alcohol inclusion complex with iodine and lithium, in addition to a broad-spectrum microbicidal action against viruses and bacteria, possesses pronounced activity in modulating antimicrobial host defence. LCI affects microbial cells ingestion by phagocytes and makes phagocytic cells undergo a burst of oxygen consumption. LCI dose- and time- dependent manner down-modulate phagocytosis due to LCI interaction with CD14 receptors and regulate the oxidative burst of phagocytic cells depending on the presence or absence of respiratory burst stimulators. The LCI effect is similar with respiratory burst low stimulant chemotactic peptides, and suppresses the oxidative burst, stimulated by opsonized E. coli. Thus, LCI could represent a topical microbicide acting both as a chemical and physical barrier against pathogens and as a pathogen-associated inflammation down-modulator. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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