Therapeutic Effect of Corneal Crosslinking on Fungal Keratitis: Efficacy of Corneal Collagen Crosslinking as an Adjuvant Therapy for Fungal Keratitis in a Tertiary Eye Hospital in South India.

Autor:	Jeyalatha Mani, Vimalin, Parthasarathy, Durgadevi, Padmanabhan, Prema, Narayanan, Niveditha, Lakshmipathy, Meena, Pachayappan, Saravana Kumar, Jayavel, Padmapriya, Therese, Kulandhai Lily, Rao Madhavan, Hajib Narahari, Jambulingam, Malathi
Předmět:	FUNGAL keratitis CORNEA TREATMENT effectiveness COLLAGEN FUNGAL growth HOSPITALS CYTOKINES VITAMIN B2 ANTIFUNGAL agents CORNEAL ulcer SPECIALTY hospitals PHOTOSENSITIZERS CHEMICAL reagents CELL receptors MYCOSES EYE infections COMBINED modality therapy OPHTHALMOLOGY ULTRAVIOLET radiation METABOLISM
Zdroj:	Ocular Immunology & Inflammation; 2021, Vol. 29 Issue 7/8, p1648-1655, 8p
Abstrakt:	Purpose: To evaluate the efficacy of CXL in treating fungal keratitis as an adjuvant therapy.Methods: Detailed clinical examination microbiological investigation was performed. Twenty fungal keratitis patients were recruited and randomized into two groups: group 1 (n= 11, standard antifungal), group 2 (n=9, corneal collagen crosslinking with standard antifungal). Corneal scraping and tear samples collected were subjected to real-time PCR targeting ITS, TLR analysis and cytokine analysis.Results: The mean time for complete resolution of ulcer for group 2 was significantly shorter compared to group 1 and the final mean BCVA was better for group 2. Expression of IL-1β, IL-8, IFN-γ significantly decreased immediately post CXL in group 2 patients. Significant downregulation of TLR 6, TLR-3, TLR-4 was observed 3-days post CXL compared to group 1 patients.Conclusion: Adjuvant effect of CXL was significant in treating fungal keratitis compared to standalone antifungal treatment. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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