| Autor: |
Mazzoni, Alessio, Vanni, Anna, Spinicci, Michele, Capone, Manuela, Lamacchia, Giulia, Salvati, Lorenzo, Coppi, Marco, Antonelli, Alberto, Carnasciali, Alberto, Farahvachi, Parham, Giovacchini, Nicla, Aiezza, Noemi, Malentacchi, Francesca, Zammarchi, Lorenzo, Liotta, Francesco, Rossolini, Gian Maria, Bartoloni, Alessandro, Cosmi, Lorenzo, Maggi, Laura, Annunziato, Francesco |
| Předmět: |
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| Zdroj: |
Frontiers in Immunology; 1/26/2022, Vol. 13, p1-8, 8p |
| Abstrakt: |
Although accumulating data have investigated the effect of SARS-CoV-2 mutations on antibody neutralizing activity, less is known about T cell immunity. In this work, we found that the ancestral (Wuhan strain) Spike protein can efficaciously reactivate CD4+ T cell memory in subjects with previous Alpha variant infection. This finding has practical implications, as in many countries only one vaccine dose is currently administered to individuals with previous COVID-19, independently of which SARS-CoV-2 variant was responsible of the infection. We also found that only a minority of Spike-specific CD4+ T cells targets regions mutated in Alpha, Beta and Delta variants, both after natural infection and vaccination. Finally, we found that the vast majority of Spike-specific CD4+ T cell memory response induced by natural infection or mRNA vaccination is conserved also against Omicron variant. This is of importance, as this newly emerged strain is responsible for a sudden rise in COVID-19 cases worldwide due to its increased transmissibility and ability to evade antibody neutralization. Collectively, these observations suggest that most of the memory CD4+ T cell response is conserved against SARS-CoV-2 variants of concern, providing an efficacious line of defense that can protect from the development of severe forms of COVID-19. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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