Recurrent Wnt medulloblastoma treated with marrow-ablative chemotherapy and autologous hematopoietic progenitor cell rescue: a dual case report and review of the literature.

Autor:	Harris, Micah K., Shatara, Margaret, Funk, Zachary, Stanek, Joseph, Boué, Daniel R., Jones, Jeremy, Finlay, Jonathan L., Abdelbaki, Mohamed S.
Předmět:	PROGENITOR cells MEDULLOBLASTOMA LITERATURE reviews CANCER chemotherapy TREATMENT effectiveness
Zdroj:	Child's Nervous System; Feb2022, Vol. 38 Issue 2, p465-472, 8p
Abstrakt:	Wnt-activated medulloblastoma (MB) confers an excellent prognosis. However, specific treatment strategies for patients with relapsed Wnt-MB are unknown. We report two patients with recurrent beta-catenin nucleopositive Wnt-MB successfully treated by incorporating marrow-ablative chemotherapy and autologous hematopoietic progenitor cell rescue (HDCx/AuHPCR). We also present a review of the literature for previously reported cases of relapsed Wnt-MB. We propose that patients with recurrent Wnt-MB may be treated using a multi-disciplinary approach that includes HDCx/AuHPCR with or without re-irradiation. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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