Optimized Chromatographic Separation and Bioevalution of Radioiodinated Ilaprazole as a New Labeled Compound for Peptic Ulcer Localization in Mice.

Autor:	Sanad, M. H., Eyssa, H. M., Marzook, F. A., Farag, A. B., Rizvi, S. F. A., Mandal, S. K., Patnaik, S. S., Fouzy, A. S. M.
Předmět:	PEPTIC ulcer STOMACH ulcers RADIOACTIVE tracers OXIDIZING agents MICE CHLORAMINE-T
Zdroj:	Radiochemistry; 2021, Vol. 63 Issue 6, p811-819, 9p
Abstrakt:	The paper describes the radiosynthesis of a new labelled chemical, [125I]iodoilaprazole. Several critical factors were optimized, namely, substrate concentration (100 µg), amount of oxidizing agent (50 µg, Chloramine-T), pH (pH 6), and reaction time (30 min). Under optimized conditions factors, the radiochemical yield of [125I]iodoilaprazole reached a maximum (98.5%). The biodistribution of [125I]iodoilaprazole in mice was investigated, and its significant absorption was demonstrated in stomach ulcers, reaching approximately 75.2 ± 0.7% ID/g at 30 min after injection. High concentration of [125I]iodoilaprazole in stomach ulcer makes this compound a promising new radiotracer for stomach ulcer imaging. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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