| Abstrakt: |
Bacterial meningitis is a dreaded infectious disease in the human pulmonary system caused by bacterial invasion and promoting inflammation. Hanjeli (Coix lacryma-jobi) seed and root oil have antioxidant, anti-inflammatory, and antibacterial properties that can be used in the treatment of bacterial meningitis. The study aims to investigate the potential of oil from C. lacryma-jobi seed and root part for bacterial meningitis treatment. The phytochemical screening was performed using standard protocols. Antibacterial activity and minimum inhibitory concentration (MIC) were conducted by the disc diffusion and two-fold dilution method. The preliminary phytochemical screening of C. lacryma-jobi shows that essential oil of root and seed part contains steroids, carotenoids, tannins, alkaloid salts, reducing compounds, flavonoid, anthracenoid, coumarin derivatives, cardenoid, anthocyanins, and saponins. The determination of total phenolic, tannin contents, and antioxidant in essential oil from the root was significantly higher (p <0.05) than the seed part. The C. lacrymajobi oil from both parts expressed the highest antimicrobial activity against Streptococcus pneumoniae and Klebsiella pneumoniae. Additionally, the lowest minimum inhibitory concentration (12.5–50 mg/mL) was observed against selected bacteria of meningitis. It is concluded that oil from C. lacryma-jobi root and seed parts contains compounds that might be used in the bacterial meningitis treatment. [ABSTRACT FROM AUTHOR] |
