| Autor: |
Pertsov, S. S., Alekseeva, I. V., Abramova, A. Yu., Nikenina, E. V., Kozlov, A. Yu., Koplik, E. V., Martyusheva, A. S. |
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| Zdroj: |
Neuroscience & Behavioral Physiology; Nov2021, Vol. 51 Issue 9, p1286-1291, 6p |
| Abstrakt: |
The dynamics of measures reflecting the intensity of metabolic processes were studied in rats after i.p. injections of lipopolysaccharide (LPS, 100 μg/kg) at the end of a single long-lasting stress load in a 24-h restraint model. The volumes of oxygen consumed and cardon dioxide exhaled and the level of heat production were measured using a Phenomaster automated modular system (TSE Systems GmbH, Germany) at 3 h, 1 day, and 8 days after exposure. These metabolic parameters were found to increase 1 day after restraint stress in animals given physiological saline. These changes illustrate intensification of metabolic processes in rats at different times after experimental stress. These alterations persisted even into the long-term period after stress exposure and were present on study day 8. Individuals given LPS showed increased oxygen consumption and carbon dioxide production on day 1 of the poststress period, along with an increase in heat exchange. On day 8 after stress with subsequent immune modulation, metabolic parameters in rats decreased such that they were no different from those in intact animals. Thus, antigenic exposure by systemic administration of LPS had no effect on stress-induced activation of metabolic processes at the early stages of the study period but prevented stable increases in the intensity of metabolism in the long-term poststress period. These results, along with previously published data, suggest that the effects of LPS, which has immunoactive properties, are linked with its modulatory action on neuroendocrine mechanisms regulating homeostasis in mammals, particularly on exposure to stress. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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