| Autor: |
Heckert, Sascha L., Bergstra, Sytske Anne, Matthijssen, Xanthe M. E., Goekoop-Ruiterman, Yvonne P. M., Fodili, Faouzia, Wolde, Saskia ten, Allaart, Cornelia F., Huizinga, Tom W. J., Ten Wolde, Saskia |
| Předmět: |
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| Zdroj: |
Annals of the Rheumatic Diseases; Feb2022, Vol. 81 Issue 2, p167-174, 8p |
| Abstrakt: |
Objectives: We investigated whether local joint swelling recurs in the same joints over time in patients with rheumatoid arthritis (RA) who are treated to target.Methods: Patients with newly diagnosed RA participating in the Behandel-Strategieën, "treatment strategies" (BeSt) study (n=508) were followed for median 10 years while receiving Disease Activity Score (DAS) ≤2.4 steered treatment. Every 3 months 68 joints were assessed for the presence of swelling. We evaluated whether baseline local joint swelling was predictive for swelling in the same joint during follow-up using a multilevel mixed-effect logistic regression model. Different strategies were used to account for missing data. A permutation test was performed to assess if joint swelling was better predicted by baseline swelling of the joint itself than by baseline swelling of randomly selected other joints.Results: In 46% of the joints that were swollen at baseline, joint swelling later recurred at least once during follow-up. Joint swelling at baseline was statistically significantly associated with swelling in the same joint during follow-up (OR 2.37, 95% CI 2.30 to 2.43, p<0.001), and also specifically with recurrent swelling in the same joint (OR 1.73, 95% CI 1.37 to 1.59, p<0.001). Local joint swelling was better predicted by baseline swelling of that particular joint than by baseline swelling of other joints (p<0.001).Conclusion: Joint swelling tends to recur locally in the joints swollen at RA onset. This suggests that local factors influence the manifestation of joint inflammation over time. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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