| Autor: |
Bannasch, Danika, Famula, Thomas, Donner, Jonas, Anderson, Heidi, Honkanen, Leena, Batcher, Kevin, Safra, Noa, Thomasy, Sara, Rebhun, Robert |
| Předmět: |
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| Zdroj: |
Canine Medicine & Genetics; 12/2/2021, Vol. 8 Issue 1, p1-9, 9p |
| Abstrakt: |
Background: Dog breeds are known for their distinctive body shape, size, coat color, head type and behaviors, features that are relatively similar across members of a breed. Unfortunately, dog breeds are also characterized by distinct predispositions to disease. We explored the relationships between inbreeding, morphology and health using genotype based inbreeding estimates, body weight and insurance data for morbidity. Results: The average inbreeding based on genotype across 227 breeds was Fadj = 0.249 (95% CI 0.235–0.263). There were significant differences in morbidity between breeds with low and high inbreeding (H = 16.49, P = 0.0004). There was also a significant difference in morbidity between brachycephalic breeds and non-brachycephalic breeds (P = 0.0048) and between functionally distinct groups of breeds (H = 14.95 P < 0.0001). Morbidity was modeled using robust regression analysis and both body weight (P < 0.0001) and inbreeding (P = 0.013) were significant (r2 = 0.77). Smaller less inbred breeds were healthier than larger more inbred breeds. Conclusions: In this study, body size and inbreeding along with deleterious morphologies contributed to increases in necessary health care in dogs. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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