| Abstrakt: |
Mental depression is a distresses person's mood, thoughts, physical health and behavior with chronic illness. The biological and emotional components are also attach with symptoms of depression. The retardation of thought, action and appetite are biological symptoms & emotional indicators include mystery, apathy and pessimism, low selfesteem consisting of feeling of guilt, inadequacy and ugliness, indecisiveness and loss of motivation. Patients with major depression have symptoms that reflect changes in brain, monoamine neurotransmitters, specifically nor epinephrine, serotonin, dopamine. The reasons for the disease include stimulation of MAO-A, inhibition of NA and 5-HT. Symptoms include the diminished interest of pleasure, feelings of worthlessness or inappropriate guilt, a decrease in appetite and libido, insomnia, and recurrent thoughts of death or suicide. Many scientists are researching plant material for treating this disorder and there are lots of publications on it. Several drug-drug interactions can also occur. These conditions create an opportunity of alternative treatment for depression by the use of medicinal plants. Since all the synthetic drugs available for the treatment of depression have various adverse effects associated with problematic interactions, our aim is to explore the potential of medicinal plants in the management of depression. The present study is proposed cassia grandis leaves have more potent activity for management of depression due to presence of more phytochemical constituents. These phytochemivcal constituents have antidepressant activity as previous scientist work. Thus, the proposed part of plant have maximum potent phyochemical constituent for justified the proposed work. Stress renders an individual to experience mental pressure and exhaustion which brings about feelings of anxiety, depression, anger and/or other negative emotions. Depression affects a person's state of mind, behaviour, health and is often associated with suicide. The use of anti-depressant drugs as therapeutic agents is associated with symptoms such as, delayed onset of action, sideeffects, drug-drug and dietary interactions, sexual dysfunction, cardiac toxicity, etc. Thus, there is need to target these issues and improve current treatment options. Medicinal plants have long been used in discovering novel treatment strategies and compounds with promising roles in treating various disease conditions. There has been an increase, worldwide, in the use of medicinal plants and herbs for developing nutraceuticals for treatment of depression and other psychiatric disorders. Medicinal plants in their natural forms are valuable as they are rich in various phytochemical compounds. These phytochemical compounds have pharmacological roles in treating various diseases conditions; apart from being widely available in nature and commercially beneficial. The phytochemical compounds in plants are constantly being explored through various experimental studies to determine the molecular basis of how medicinal plants work in relation to drugs and diseases and to develop neutraceuticals for improving conditions. The various mechanisms of anti-depressant action of some of proposed plants parts like roots, stem, leaves, flowers, fruit; phytochemical compounds showing anti-depressant activity such flavanoids, steroids, saponins, sugars, lectins, alkaloids, etc.; and various anti-depressant screening models used such as tail suspension test, forced swim test, chronic unpredictable stress test, sucrose preference test, monoamine oxidase inhibition assay, learned helplessness test, open field test, hole board test, etc. However, mechanistic evaluation of many of these plants still needs to be investigated and explored. [ABSTRACT FROM AUTHOR] |
