Recommendations for Practical Use of Metformin, a Central Pharmacological Therapy in Type 2 Diabetes.

Autor: Vieira, Inês H., Barros, LuÍsa M., Baptista, Carla F., Rodrigues, DÍrcea M., Paiva, Isabel M.
Předmět:
Zdroj: Clinical Diabetes; Jan2022, Vol. 40 Issue 1, p97-107, 11p
Abstrakt: The article presents the discussion on Metformin being a biguanide derived from the plant Galega officinalis. Topics include Metformin influencing AMP-activated protein kinase and the fructose-1,6-bisphosphatase pathway leading to a decrease in the AMP/ATP ratio and reducing the energy available for neoglycogenesis; and an increment in intestinal glucose expenditure and an increase in the secretion of GI incretins.
Databáze: Complementary Index