| Autor: |
Rangaraj, Seshasayi, Islam, Mobarakol, VS, Vibashan, Wijethilake, Navodini, Uppal, Utkarsh, See, Angela An Qi, Chan, Jasmine, James, Michael Lucas, King, Nicolas Kon Kam, Ren, Hongliang |
| Předmět: |
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| Zdroj: |
Medical & Biological Engineering & Computing; Feb2022, Vol. 60 Issue 2, p337-348, 12p, 2 Color Photographs, 1 Black and White Photograph, 3 Charts, 7 Graphs |
| Abstrakt: |
Segmentation of intracerebral hemorrhage (ICH) helps improve the quality of diagnosis, draft the desired treatment methods, and clinically observe the variations with healthy patients. The clinical utilization of various ICH progression scoring systems has limitations due to the systems' modest predictive value. This paper proposes a single pipeline of a multi-task model for end-to-end hemorrhage segmentation and risk estimation. We introduce a 3D spatial attention unit and integrate it into the state-of-the-art segmentation architecture, UNet, to enhance the accuracy by bootstrapping the global spatial representation. We further extract the geometric features from the segmented hemorrhage volume and fuse them with clinical features such as CT angiography (CTA) spot, Glasgow Coma Scale (GCS), and age to predict the ICH stability. Several state-of-the-art machine learning techniques such as multilayer perceptron (MLP), support vector machine (SVM), gradient boosting, and random forests are applied to train stability estimation and to compare the performances. To align clinical intuition with model learning, we determine the shapely values (SHAP) and explain the most significant features for the ICH risk scoring system. A total of 79 patients are included, of which 20 are found in critical condition. Our proposed single pipeline model achieves a segmentation accuracy of 86.3%, stability prediction accuracy of 78.3%, and precision of 82.9%; the mean square error of exact expansion rate regression is observed to be 0.46. The SHAP analysis reveals that CTA spot sign, age, solidity, location, and length of the first axis of the ICH volume are the most critical characteristics that help define the stability of the stroke lesion. We also show that integrating significant geometric features with clinical features can improve the ICH progression scoring by predicting long-term outcomes. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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