Integrated analysis of plasma and single immune cells uncovers metabolic changes in individuals with COVID-19.

Autor: Lee, Jihoon W., Su, Yapeng, Baloni, Priyanka, Chen, Daniel, Pavlovitch-Bedzyk, Ana Jimena, Yuan, Dan, Duvvuri, Venkata R., Ng, Rachel H., Choi, Jongchan, Xie, Jingyi, Zhang, Rongyu, Murray, Kim, Kornilov, Sergey, Smith, Brett, Magis, Andrew T., Hoon, Dave S. B., Hadlock, Jennifer J., Goldman, Jason D., Price, Nathan D., Gottardo, Raphael
Zdroj: Nature Biotechnology; Jan2022, Vol. 40 Issue 1, p110-120, 11p
Abstrakt: A better understanding of the metabolic alterations in immune cells during severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection may elucidate the wide diversity of clinical symptoms experienced by individuals with coronavirus disease 2019 (COVID-19). Here, we report the metabolic changes associated with the peripheral immune response of 198 individuals with COVID-19 through an integrated analysis of plasma metabolite and protein levels as well as single-cell multiomics analyses from serial blood draws collected during the first week after clinical diagnosis. We document the emergence of rare but metabolically dominant T cell subpopulations and find that increasing disease severity correlates with a bifurcation of monocytes into two metabolically distinct subsets. This integrated analysis reveals a robust interplay between plasma metabolites and cell-type-specific metabolic reprogramming networks that is associated with disease severity and could predict survival. The immune cells of individuals with COVID-19 show metabolic changes. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
Externí odkaz: