| Autor: |
GOLUBEVA, TATIANA, OBYEDKOV, VIKTOR, DOKUKINA, TATIANA, KAMINSKAYA, YULIA, GOLOENKO, INNA |
| Předmět: |
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| Zdroj: |
Polish Journal of Applied Sciences; 2020, Vol. 6 Issue 2, p29-33, 5p |
| Abstrakt: |
The objective of the study was to investigate the genetic features that affect the metabolic rate of antipsychotics in patients with schizophrenia being frequently (at least once a year) treated in -hospital. The focus of the study was the genetic polymorphism CYP2D6*4 (1846G> A, rs3892097). A significant correlation between the presence of the CYP2D6*4 genetic polymorphism and frequent hospital stays of patients with schizophrenia was found. One of the probable reasons for this correlation may be a poor efficiency of drug therapy due to the slow metabolism of antipsychotics, most of which are the substrates for the CYP2D6 isoenzyme of cytochrome P450. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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