| Autor: |
Dubertret, L., Averbeck, D., Zajdela, F., Bisagni, E., Moustacchi, E., Touraine, R., Latarjett, R. |
| Předmět: |
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| Zdroj: |
British Journal of Dermatology; Oct1979, Vol. 101 Issue 4, p379-389, 11p |
| Abstrakt: |
The carcinogenic risk of photochemotherapy (PUVA) with bi-functional furocoumarins such as 8-methoxypsoralen (8-MOP) which form cross-links in cellular DNA has initiated a search for active but less hazardous psoralens. A new compound, 3-carbethoxypsoralen (3-CPs), studied in the yeast Saccharomyces cerevisiae (eukaryote), has been shown to be very photoactive on DNA and to form only mono-additions to DNA. These Lesions appear to be more easily repaired than the cross-links induced by 8-MOP. 3-CP5 produces less nuclear genetic events such as nuclear mutations and mitotic crossovers, but more cytoplasmic `petite' mutations (damage to mitochondrial DNA) than 8-MOP. In mice it was demonstrated that after local or intra-peritoneal administration, in contrast to 8-MOP, 3-CPs is non-toxic, non-erythematogenic, and non-carcinogenic. A study of ten psoriatic patients has shown that local applications of 3-CP5 plus UV-A exhibit about the same therapeutic activity for the clearing of psoriatic lesions as local treatment with 8-MOP plus UV-A, but without any localized hyperpigmentation. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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