| Autor: |
Chandran, Vijayendran, Mei-Ling Bermúdez, Koka, Mert, Chandran, Brindha, Pawale, Dhanashri, Vishnubhotla, Ramana, Alankar, Suresh, Maturi, Raj, Subramaniam, Balachundhar, Sadhasivam, Senthilkumar |
| Předmět: |
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| Zdroj: |
Proceedings of the National Academy of Sciences of the United States of America; 12/21/2021, Vol. 118 Issue 51, p1-12, 12p |
| Abstrakt: |
The positive impact of meditation on human well-being is well documented, yet its molecular mechanisms are incompletely understood. We applied a comprehensive systems biology approach starting with whole-blood gene expression profiling combined with multilevel bioinformatic analyses to characterize the coexpression, transcriptional, and protein-protein interaction networks to identify a meditation-specific core network after an advanced 8-d Inner Engineering retreat program. We found the response to oxidative stress, detoxification, and cell cycle regulation pathways were down-regulated after meditation. Strikingly, 220 genes directly associated with immune response, including 68 genes related to interferon signaling, were up-regulated, with no significant expression changes in the inflammatory genes. This robust meditation-specific immune response network is significantly dysregulated in multiple sclerosis and severe COVID-19 patients. The work provides a foundation for understanding the effect of meditation and suggests that meditation as a behavioral intervention can voluntarily and nonpharmacologically improve the immune response for treating various conditions associated with excessive or persistent inflammation with a dampened immune system profile. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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