| Autor: |
Wong, Christina S. M., Yap, Desmond Y. H., Ip, Patrick, Wong, Wilfred H. S., Chua, Gilbert T., Yeung, Chi‐Keung, Chan, Henry H. L., Kwok, Janette S. Y. |
| Předmět: |
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| Zdroj: |
International Journal of Dermatology; Feb2022, Vol. 61 Issue 2, p184-190, 7p |
| Abstrakt: |
Background: HLA‐B*15:11 is associated with carbamazepine (CBZ)‐induced severe cutaneous adverse drug reactions (SCARs) in Japanese and some Asian populations, but such data remains relatively limited in Chinese. Routine HLA‐B*15:02 screening is mandatory before CBZ commencement, however, SCARs related to CBZ were still observed in non‐HLA*B‐15:02 carriers. Objective: We aimed to find out the prevalence of HLA‐B*15:11 in Chinese patients and its associations with CBZ‐induced SCARs. Method: We screened 8,328 blood samples collected for HLA allele typing before CBZ commencement during the period of January 2014 to December 2019. In HLA‐B*15:02 negative Chinese patients, HLA‐B*15:11 status were further screened, and the incidence of SCARs in the CBZ group was compared with the control group without CBZ use. Result: In this cohort, 1416 out of 8328 patients (17%) tested HLA‐B*15:02 positive and were advised to avoid CBZ, while 80 (0.96%) were found to be HLA‐B*15:11 positive. In 6911 (83%) patients who tested HLA‐B*15:02 negative, 70 (1.01%) were HLA‐B*15:11 positive. Five out of 70 (7.14%) patients had SCARs. The incidence of SCARs in HLA‐B*15:11 carriers who received CBZ was significantly higher than those without CBZ (17.4% [4/23] vs. 2.13% [1/47], P = 0.037*). The odds ratio was 9.68 (95% CI 1.02–92.4, P = 0.048*). These included: one Stevens‐Johnson syndrome (SJS), two DRESS, and one MPE after CBZ use, while one developed MPE after phenytoin use in control. Conclusion: HLA‐B*15:11 is a potential risk factor of CBZ‐induced SCARs in HLA‐B*15:02 negative Chinese patients. Further screening of HLA‐B*15:11 status in those HLA‐B*15:02 negative patients is recommended to avoid undesirable SCARs. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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