| Autor: |
Limberg, Jacqueline K., Johansson, Rebecca E., Carter, Katrina J., Peltonen, Garrett L., Harrel, John W., Kellawan, J. Mikhail, Eldridge, Marlowe W., Sebranek, Joshua J., Walker, Benjamin J., Schrage, William G. |
| Předmět: |
|
| Zdroj: |
American Journal of Physiology: Heart & Circulatory Physiology; Jan2022, Vol. 332 Issue 1, pH25-H35, 11p |
| Abstrakt: |
Central adiposity is associated with greater sympathetic support of blood pressure. b-adrenergic receptors (b-AR) buffer sympathetically mediated vasoconstriction and b-AR-mediated vasodilation is attenuated in preclinical models of obesity. With this information, we hypothesized b-AR vasodilation would be lower in obese compared with normal weight adults. Because b-AR vasodilation in normal weight adults is limited by cyclooxygenase (COX) restraint of nitric oxide synthase (NOS), we further explored the contributions of COX and NOS to b-AR vasodilation in this cohort. Forearm blood flow (FBF, Doppler ultrasound) and mean arterial blood pressure (MAP, brachial arterial catheter) were measured and forearm vascular conductance (FVC) was calculated (FVC = FBF/MAP). The rise in FVC from baseline (DFVC) was quantified during graded brachial artery infusion of isoproterenol (Iso, 1-12 ng/100 g/min) in normal weight (n = 36) and adults with obesity (n = 22) (18-40 yr old). In a subset of participants, Iso-mediated vasodilation was examined before and during inhibition of NOS [NG-monomethyl-L-arginine (L-NMMA)], COX (ketorolac), and NOS þ COX (L-NMMA þ ketorolac). Iso-mediated increases in FVC did not differ between groups (P = 0.57). L-NMMA attenuated Iso-mediated DFVC in normal weight (P = 0.03) but not adults with obesity (P = 0.27). In normal weight adults, ketorolac increased Iso-mediated DFVC (P < 0.01) and this response was lost with concurrent L-NMMA (P = 0.67). In contrast, neither ketorolac (P = 0.81) nor ketorolac þ L-NMMA (P = 0.40) altered Iso-mediated DFVC in adults with obesity. Despite shifts in COX and NOS, b-AR vasodilation is preserved in young adults with obesity. These data highlight the presence of a compensatory shift in microvascular control mechanisms in younger humans with obesity. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
|
