| Autor: |
TAKASHI TANIKAWA, MASASHI KITAMURA, YASUHIRO HAYASHI, TAKAMI YOKOGAWA, YUTAKA INOUE |
| Předmět: |
|
| Zdroj: |
In Vivo; Jan/Feb2022, Vol. 36 Issue 1, p227-232, 6p |
| Abstrakt: |
Background/Aim: The cannabinoid 2 (CB2) receptor is an important regulator of immunoinflammatory responses. Crude drugs commonly used in Japanese traditional Kampo medicine have displayed anti-inflammatory effects; however, few studies have reported that these effects are mediated via CB2 receptor signaling. Therefore, this study aimed to elucidate CB2 receptor-related anti-inflammatory regulation in crude drugs. Materials and Methods: The ethanol extracts of 34 crude drugs listed in the Japanese Pharmacopeia were tested, and the inhibitory effects on lipopolysaccharide (LPS)-induced nitric oxide (NO) production were evaluated in murine macrophage RAW 264 cells. Results: The extracts of Curcumae Longae Rhizoma (dried rhizome of Curcuma longa) and Saussureae Radix (dried root of Saussurea lappa) significantly inhibited NO production and attenuated the LPS-induced decrease in CB2 receptor mRNA expression. Conclusion: Curcumae Longae Rhizoma and Saussureae Radix can modulate the CB2- receptor-related anti-inflammatory regulation in macrophages. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
|
