COVID-19 and Parkinson's disease: a casual association or a possible second hit in neurodegeneration?

Autor: Cavallieri, Francesco, Fioravanti, Valentina, Toschi, Giulia, Grisanti, Sara, Napoli, Manuela, Moratti, Claudio, Pascarella, Rosario, Versari, Annibale, Fraternali, Alessandro, Casali, Massimiliano, Paul, Jefri J., Moro, Elena, Bauer, Peter, Zedde, Marialuisa, Valzania, Franco
Předmět:
Zdroj: Journal of Neurology; Jan2022, Vol. 269 Issue 1, p59-61, 3p
Abstrakt: Before COVID-19 infection, no Parkinson's Disease (PD) prodromal symptoms were ever noted by the patient and his family. Therefore, in our patients, the COVID-19 infection could have acted as an infectious second hit, like the "double hit" hypothesis of PD [[7]], unmasking an underlying preclinical PD linked to a genetic predisposition [[2]]. However, the presence of decreased DaTscan™ uptake in all of the reported cases, which would be unlikely to occur within a short period of time, supports a possible conversion from prodromal to symptomatic PD promoted by the COVID-19 infection [[4]]. [Extracted from the article]
Databáze: Complementary Index
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