IL-23R Variant rs11805303 Is Associated With Susceptibility to the Development of Cutaneous Leishmaniasis in Leishmania guyanensis-Infected Individuals.

Autor:	Silva, Lener Santos da, Júnior, José do Espírito Santo, Mesquita, Tirza Gabrielle Ramos de, Santos, Veronica Alice Marinho, Souza, Josué Lacerda de, Araújo, Felipe Jules de, Júnior, Cláudio Marcello da Silveira, Silva, Cilana Chagas da, Queiroz, Krys Layane Guimarães Duarte, Sequera, Héctor David Graterol, Guerra, Marcus Vinitius de Farias, Souza, Mara Lúcia Gomes de, Ramasawmy, Rajendranath, Santos da Silva, Lener, Santo Júnior, José do Espírito, de Mesquita, Tirza Gabrielle Ramos, de Souza, Josué Lacerda, de Araújo, Felipe Jules, da Silveira Júnior, Cláudio Marcello, da Silva, Cilana Chagas
Předmět:	CUTANEOUS leishmaniasis LEISHMANIA LEISHMANIASIS INTERLEUKIN-17 ODDS ratio LEISHMANIASIS diagnosis INTERLEUKINS RESEARCH RESEARCH methodology GENETIC polymorphisms CELL receptors CASE-control method EVALUATION research COMPARATIVE studies
Zdroj:	Journal of Infectious Diseases; 1/1/2022, Vol. 225 Issue 1, p163-171, 9p
Abstrakt:	Background: Emerging evidence suggests that the interleukin (IL) 17/ IL-23 axis may play a role in the pathogenesis of leishmaniasis. Our aim was to investigate whether the IL-23R variant rs11805303 is a risk factor for the development of cutaneous leishmaniasis (CL) in Leishmania guyanensis-infected individuals.Methods: We genotyped by polymerase chain reaction-restriction fragment length polymorphism the rs11805303 C/T in 828 patients with CL and 806 healthy individuals. Plasma tumor necrosis factor-α, IL-6, interferon-γ, IL-1β, and IL-17 were measured with the Bioplex assay.Results: The distribution of the genotypes differed between patients with CL and healthy controls with a common odds ratio of 1.78 (P = 2.2 × 10-11) for the disease-associated T allele. Leishmania guyanensis-infected individuals homozygous for the T allele show a 200% increased risk of progressing to disease development, with a 95% confidence interval ranging from 81% to 400% (P = 9.9 × 10-6) in comparison to individuals homozygous for the C allele. Males homozygous for the T allele have higher plasma levels of IL-17 compared with heterozygous or homozygous CC individuals.Conclusions: The present association of the IL-23R variant rs11805303 with the development of CL suggests that the IL-17/IL-23 axis may play an important role in the pathogenesis of CL. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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