| Autor: |
Rajan, Roopa, Garg, Kanwaljeet, Saini, Arti, Radhakrishnan, Divya M., Carecchio, Miryam, BK, Binukumar, Singh, Manmohan, Srivastava, Achal K. |
| Předmět: |
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| Zdroj: |
Movement Disorders Clinical Practice; Jan2022, Vol. 9 Issue 1, p31-37, 7p |
| Abstrakt: |
Background: Early evidence suggests good response to pallidal deep brain stimulation (DBS) in DYT‐KMT2B. Objectives: We aimed to conduct a systematic review and meta‐analysis to assess outcomes and identify predictors of good outcome following GPi‐DBS in DYT‐KMT2B. Methods: We searched MEDLINE, Cochrane and MDS‐abstracts databases using the MeSH terms "KMT2B and DYT28". We included studies that reported objective outcomes following GPi‐DBS in DYT‐KMT2B. The BFMDRS‐M (Burke‐Fahn‐Marsden Dystonia Rating Scale‐ Movement) total scores pre‐ and post‐surgery were used to quantify outcomes. We calculated pooled effects using a random effects meta‐analysis and used meta‐regression to identify potential effect modifiers. Multiple linear regression using individual patient data was used to identify predictors of good outcome (>50% improvement from baseline on BFMDRS‐M). Results: Initial searches screened 132 abstracts of which 34 full‐text articles were identified to be of potential interest. Ten studies reporting 42 individual patients, met the inclusion/exclusion criteria and were included in the final review. The mean age at onset was 6.4 ± 5.7 years and 40% were male. The median follow‐up was 12 months (range: 1–264 months). GPi‐DBS resulted in median BFMDRS‐M improvement of 42.7% (range: −103.5% to 95.9%) postoperatively. Pooled proportion of patients experiencing clinical improvement >50% on BFMDRS‐M was 41% (95% CI: 27%–57%). Male gender [β: 22.6, 95% CI: 8.0–37.3, P = 0.004), and higher pre‐operative BFMDRS‐M score [β: 0.62, 95% CI: 0.36–0.87, P < 0.001) were independently associated with better outcome. Conclusion: KMT2B‐associated dystonia responds effectively to pallidal stimulation. The outcome is better in males and those with more severe dystonia at baseline. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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