| Autor: |
Li, Sen, Deng, Hongying, Han, Zhaoyu, Cai, Yanfei, Jin, Jian, Yang, Zhaoqi |
| Předmět: |
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| Zdroj: |
NANO; Dec2021, Vol. 16 Issue 12, p1-10, 10p |
| Abstrakt: |
Abundant investigators have devoted their efforts to proceed the development of novel strategies aimed at anti-tumor through regulating gene expression negatively. Flap structure-specific endonuclease 1 (FEN1) received widespread attention in becoming a potential target for breast cancer. In this study, a prominent protocol based on small molecular nucleic acids was reasonably demonstrated. Various oligonucleotides containing FEN1 cleavage site and anti-miRNA21 sequences were designed and synthesized as a kind of disturbance factor to FEN1 and miRNA21. In order to obtain an ideal therapeutic outcome, graphene oxide (GO) was also employed, which rendered the whole system with photothermal therapy (PTT) effect. Finally, a novel trinity treatment system came into being with the characteristic of combined therapy involving miRNA21 silencing, FEN1 inhibition and PTT. In short, it is our hope that the designed multifunctional system could provide a promising use for the development of anti-tumor therapy in the foreseeable future. In the present study, a trinity therapy, based on FEN1 inhibition, miRNA21 interruption and PTT with the characteristics of higher safety compared with chemical compounds, was constructed. Above all, the designed trinity treatment took effect perfectly and exhibited 56% tumor inhibition rate to breast cancer cells. The newly designed multifunctional nucleic acid structure could serve as a firm basis for the development of anticancer drugs depended on small molecular nucleic acids. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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