| Autor: |
Naguib, Abdel-moniem, Abdel-Samad, Abdel-kader Morsy, Sharaf, Osama M., Hamed, Ibrahim M., Soltan, Shaimaa I., Hussein, Mona M. |
| Předmět: |
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| Zdroj: |
Jordan Journal of Biological Sciences; Dec2021, Vol. 14 Issue 4, p699-707, 9p |
| Abstrakt: |
Diabetes is a metabolic disease that is very common in developing countries and responsible for the death of over 1.5 million people each year. This study aimed to investigate the anti-diabetic effect of different types of synbiotic yogurt on experimental rats. Four different types of synbiotic yogurt supplemented with inulin and microencapsulated probiotics (Lactobacillus acidophilus CH2, Lactobacillus plantarum DSA 20174, Lactobacillus rhamnosus NRRL B-442, Bifidobacterium lactis LB-12) were used. A fifth type of yogurt supplemented with inulin alone was also prepared. The antidiabetic effect of different synbiotic yogurt was evaluated in diabetic rats. The results showed that the microencapsulation had improved the survival of probiotic in yogurt samples. The yogurt samples supplemented with inulin and microencapsulated L. acidophilus have a mean viability (8.6 ±0.1 log CFU/g) on the seventh day higher, but not significant, than the viability at zero time (8.1 ±0.1 log CFU/g). The glucose and total cholesterol levels have significantly decreased (132 mg/dL and 72 ±5 mg/dL at P<0.05 respectively) in diabetic rats that were fed with yogurt supplemented with inulin and L. acidophilus compared to the diabetic control group (glucose 360 mg/dL and total cholesterol 118 ±4 mg/dL). The administration of yogurt supplemented with inulin and L. rhamnosus and yogurt supplemented with inulin and B. lactis were the most promising in improving plasma ALT (26 ±1 U/L) and AST (32 ±1 U/L) levels respectively, compared to those of diabetic control group (ALT 127 ±4 U/L and AST 69 ±0.8 U/L). A significant reduction (P<0.05) was also recorded in the levels of creatinine (0.75 ±0.09 mg/dL) and urea (30 ±0.4 mg/dL) in diabetic rats that were fed yogurt supplemented with inulin and L. plantarum compared to that of the diabetic control group (creatinine 3.08 ±0.07 mg/dL and urea 72 ±2 mg/dL). In general, the results in the current study provided evidence that using the microencapsulation technique can enhance the viability and the performance of the probiotic bacteria. The results also support the application of probiotic bacteria in ameliorating type-2 diabetes and reducing its complications. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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