| Autor: |
Schroeder, Maren K., Liu, Bin, Hinshaw, Robert G., Park, Mi-Ae, Wang, Shuyan, Dubey, Shipra, Liu, Grace Geyu, Shi, Qiaoqiao, Holton, Peter, Reiser, Vladimir, Jones, Paul A., Trigg, William, Di Carli, Marcelo F., Caldarone, Barbara J., Williams, Jacqueline P., O'Banion, M. Kerry, Lemere, Cynthia A. |
| Předmět: |
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| Zdroj: |
International Journal of Molecular Sciences; Dec2021, Vol. 22 Issue 24, p13305-13305, 1p |
| Abstrakt: |
Space radiation presents a substantial threat to travel beyond Earth. Relatively low doses of high-energy particle radiation cause physiological and behavioral impairments in rodents and may pose risks to human spaceflight. There is evidence that 56Fe irradiation, a significant component of space radiation, may be more harmful to males than to females and worsen Alzheimer's disease pathology in genetically vulnerable models. Yet, research on the long-term, sex- and genotype-specific effects of 56Fe irradiation is lacking. Here, we irradiated 4-month-old male and female, wild-type and Alzheimer's-like APP/PS1 mice with 0, 0.10, or 0.50 Gy of 56Fe ions (1GeV/u). Mice underwent microPET scans before and 7.5 months after irradiation, a battery of behavioral tests at 11 months of age and were sacrificed for pathological and biochemical analyses at 12 months of age. 56Fe irradiation worsened amyloid-beta (Aβ) pathology, gliosis, neuroinflammation and spatial memory, but improved motor coordination, in male transgenic mice and worsened fear memory in wild-type males. Although sham-irradiated female APP/PS1 mice had more cerebral Aβ and gliosis than sham-irradiated male transgenics, female mice of both genotypes were relatively spared from radiation effects 8 months later. These results provide evidence for sex-specific, long-term CNS effects of space radiation. [ABSTRACT FROM AUTHOR] |
| Databáze: |
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