| Autor: |
Smith, Matthew J, Dempsey, Sandi G, Veale, Robert WF, Duston-Fursman, Claudia G, Rayner, Chloe A F, Javanapong, Chettha, Gerneke, Dane, Dowling, Shane G, Bosque, Brandon A, Karnik, Tanvi, Jerram, Michael J, Nagarajan, Arun, Rajam, Ravinder, Jowsey, Alister, Cutajar, Samuel, Mason, Isaac, Stanley, Roderick G, Campbell, Andrew, Malmstrom, Jenny, Miller, Chris H |
| Předmět: |
|
| Zdroj: |
Journal of Biomaterials Applications; Jan2022, Vol. 36 Issue 6, p996-1010, 15p |
| Abstrakt: |
Decellularized extracellular matrix (dECM)–based biomaterials are of great clinical utility in soft tissue repair applications due to their regenerative properties. Multi-layered dECM devices have been developed for clinical indications where additional thickness and biomechanical performance are required. However, traditional approaches to the fabrication of multi-layered dECM devices introduce additional laminating materials or chemical modifications of the dECM that may impair the biological functionality of the material. Using an established dECM biomaterial, ovine forestomach matrix, a novel method for the fabrication of multi-layered dECM constructs has been developed, where layers are bonded via a physical interlocking process without the need for additional bonding materials or detrimental chemical modification of the dECM. The versatility of the interlocking process has been demonstrated by incorporating a layer of hyaluronic acid to create a composite material with additional biological functionality. Interlocked composite devices including hyaluronic acid showed improved in vitro bioactivity and moisture retention properties. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
|
