| Autor: |
Machado, Pedro Henrique Alves, Paixão, Drielly Aparecida, Lino, Ricardo Campos, de Souza, Tiago Rodrigues, de Souza Bontempo, Nayara Júnia, Sousa, Luana Munique, Van Petten de Vasconcelos Azevedo, Fernanda, Orsolin, Priscila Capelari, Lima, Paula Marynella Alves Pereira, Martins, Isabella Castro, da Costa Guerra, Joyce Ferreira, Teixeira, Samuel Cota, Araújo, Thaise Gonçalves, Goulart, Luiz Ricardo, Morelli, Sandra, Guerra, Wendell, de Oliveira Júnior, Robson José |
| Předmět: |
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| Zdroj: |
Scientific Reports; 12/27/2021, Vol. 11 Issue 1, p1-15, 15p |
| Abstrakt: |
The thin line between efficacy and toxicity has challenged cancer therapy. As copper is an essential micronutrient and is important to tumor biology, CuII complexes emerged as an alternative to chemotherapy; however, its biological properties need to be better understood. Thus, we report in vitro the antitumor effects of two CuII complexes named [Cu(4-fh)(phen)(ClO4)2] (complex 1) and [Cu(4-nh)(phen)(ClO4)2]·H2O (complex 2), in which 4-fh = 4-fluorophenoxyacetic acid hydrazide; 4-nh = 4-nitrobenzoic hydrazide and phen = 1,10-phenanthroline. Both complexes presented cytotoxic activity against tumor cells, but only complex 1 showed significant selectivity. Complex 1 also induced DNA-damage, led to G0/G1 arrest and triggered apoptosis, which was initiated by an autophagy dysfunction. The significant in vitro selectivity and the action mechanism of complex 1 are noteworthy and reveal this prodrug as promising for anticancer therapy. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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