A novel isosteviol‐based bifunctional squaramide organocatalyst for enantioselective Michael addition of acetylacetone to nitroolefins.

Autor:	Ma, Zhiwei, Liu, Zhijing, Wang, Chuanchuan, Chen, Xiaopei, Tao, Jingchao, Lv, Quanjian
Předmět:	NITROALKENES ACETYLACETONE DERACEMIZATION STEVIOSIDE NATURAL products HYDROGEN bonding
Zdroj:	Chirality; Jan2022, Vol. 34 Issue 1, p77-85, 9p
Abstrakt:	Chiral amine‐squaramide is a kind of effective hydrogen bond donor bifunctional catalyst to promote many asymmetric transformations. In this paper, novel chiral tertiary amine‐squaramide derived from the natural product of the stevioside was developed and applied into the asymmetric Michael addition of acetylacetone to nitroolefins. This asymmetric reaction performed well, and a series of enantiomerically enriched compounds were obtained in high yields (up to 96%) with excellent enantioselectivities (up to 99% ee). [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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