| Autor: |
Monteiro, Marta, Lavrador, Ana S., Teles, Aires Oliva, Couto, Ana, Carvalho, António Paulo, Enes, Paula, Rosales, Patricia Díaz |
| Předmět: |
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| Zdroj: |
Aquaculture Research; Dec2021, Vol. 52 Issue 12, p6420-6433, 14p |
| Abstrakt: |
The search for natural immunotherapeutic agents has become increasingly important for fish disease treatment and prophylaxis. The present research explored the effects of macro- and microalgal extracts on zebrafish juvenile growth and immune status. A plant-based diet was used as a control (diet C), and seven other diets were prepared similar to diet C, supplemented with 10 g Kg-1 of each algal extract (Fucus vesiculosus, F; Nannochloropsis gaditana, N; and Ulva rigida, U), or a combination of extracts (diets FN, FU, NU and FNU). A fishmeal-based diet was included as a positive control (diet C+). Diet C+ outperformed the remaining dietary treatments, growth-wise. None of the extracts improved diet C negative effects. However, the inclusion of U. rigida and N. gaditana extracts promoted an immunomodulatory action after 1 week of trial, by upregulating cytokine expression. This effect subsided after 30 days, suggesting tolerance may be developed over time. In contrast, effects on growth-related genes were still observed after 5 weeks of feeding F, N, U and FN diets. Algal extract dietary inclusion did not compromise intestinal integrity. These findings support the potential of algal extracts as functional feed additives during short periods (<30 days) to enhance immunomodulation. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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