| Autor: |
Sichero, Laura, Tagliabue, Marta, Mota, Giana, Ferreira, Silvaneide, Nunes, Rafaella A. L., Castañeda, Carlos Arturo, Castillo, Miluska, Correa, Rita Mariel, Perdomo, Sandra, Rodríguez‐Urrego, Paula A., Matos, Leandro Luongo, Mohssen, Ansarin, Gheit, Tarik, Tommasino, Massimo, Chiocca, Susanna, Villa, Luisa Lina |
| Předmět: |
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| Zdroj: |
Head & Neck; Jan2022, Vol. 44 Issue 1, p122-133, 12p |
| Abstrakt: |
Background: Human papillomavirus (HPV)‐driven head/neck squamous cell carcinomas (HNSCC) prevalence varies globally. We evaluated HPV DNA and p16INK4a in formalin fixed paraffin embedded (FFPE) HNSCC from Argentina, Brazil, Colombia, and Peru. Methods: HPV was genotyped by PCR‐hybridization. All HPV DNA positive and some HPV DNA negative cases underwent p16INK4a immunohistochemistry. Results: HPV DNA was detected in 32.8%, 11.1%, and 17.8% of oropharyngeal (OPC), oral cavity (OCC) and laryngeal (LC) cancers, respectively. OPC HPV prevalence was higher in Colombia (94.7%), and Argentina (42.6%) compared to Brazil (10.6%) and Peru (0.0%). HPV‐16 was the most detected. Other HPVs were found in LC. Higher rates of p16INK4a positivity were observed among HPV positive OPC/OCC cases compared to LC cases. Conclusions: Our results support a role for HPV‐16 in a subset of HNSCC, corroborate the heterogeneity observed in samples from different countries, and contribute additional etiological and biomarkers information in tumors of significant impact worldwide. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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