| Abstrakt: |
Single‐cell technologies capture cellular heterogeneity to focus on previously poorly described subpopulations of cells. Work by our laboratory and many others has metagenomically characterised a low biomass intrauterine microbial community, alongside microbial transcripts, antigens and metabolites, but the functional importance of low biomass microbial communities in placental immuno‐microenvironments is still being elucidated. Given their hypothesised role in modulating inflammation and immune ontogeny to enable tolerance of beneficial microbes while warding off pathogens, there is a need for single‐cell resolution. Herein, we summarise the potential for mechanistic understanding of these and other key fundamental early developmental processes by applying single‐cell approaches. Single‐cell approaches will be vital to understanding how placenta cells differentiate maternal and microbial antigens #BJOG #scRNA‐seq @norsketexsci @barrozophd. [ABSTRACT FROM AUTHOR] |
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