Untargeted Molecular Analysis of Exhaled Breath as a Diagnostic Test for Ventilator-Associated Lower Respiratory Tract Infections (BreathDx).

Autor:	van Oort, Pouline M. P., Nijsen, Tamara M., White, Iain R., Knobel, Hugo H., Felton, Timothy, Rattray, Nicholas, Lawal, Oluwasola, Bulut, Murtaza, Ahmed, Waqar, Artigas, Antonio, Povoa, Pedro R., Martin-Loeches, Ignacio, Weda, Hans, Goodacre, Royston, Schultz, Marcus J., Dark, Paul M., Fowler, Stephen J., Bos, Lieuwe D., van Oort, Pouline Mp, BreathDx Consortium
Předmět:	VENTILATOR-associated pneumonia RESPIRATORY infections BREATH tests DIAGNOSIS methods RESEARCH MECHANICAL ventilators RESEARCH methodology EVALUATION research COMPARATIVE studies RESEARCH funding ROUTINE diagnostic tests RESPIRATION
Zdroj:	Thorax; Jan2022, Vol. 77 Issue 1, p79-81, 3p
Abstrakt:	Patients suspected of ventilator-associated lower respiratory tract infections (VA-LRTIs) commonly receive broad-spectrum antimicrobial therapy unnecessarily. We tested whether exhaled breath analysis can discriminate between patients suspected of VA-LRTI with confirmed infection, from patients with negative cultures. Breath from 108 patients suspected of VA-LRTI was analysed by gas chromatography-mass spectrometry. The breath test had a sensitivity of 98% at a specificity of 49%, confirmed with a second analytical method. The breath test had a negative predictive value of 96% and excluded pneumonia in half of the patients with negative cultures. Trial registration number: UKCRN ID number 19086, registered May 2015. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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