Switchable delivery of small interfering RNA using a negatively charged pH-responsive polyethylenimine-based polyelectrolyte complex.

Autor: S. -Ja. Tseng, Yi-Fang Zeng, Yu-Fan Deng, Pan-Chyr Yang, Je-Ruei Liu, Kempson, Ivan M.
Předmět:
Zdroj: Chemical Communications; 4/4/2013, Vol. 49 Issue 26, p2670-2672, 3p
Abstrakt: A small interfering RNA (siRNA)-loaded polyelectrolyte constructed with branched polyethylenimine (bPEI) and copolymers, consisting of polyethylene glycol (PEG), histidine (His), and glutamic acid (Glu), was developed in order to provide a tumor acidosis-triggered delivery system with low cytotoxicity. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index