| Autor: |
Gündüz, Serhat, Nitta, Nobuhiro, Vibhute, Sandip, Shibata, Sayaka, Mayer, Martin E., Logothetis, Nikos K., Aoki, Ichio, Angelovski, Goran |
| Předmět: |
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| Zdroj: |
Chemical Communications; 2/18/2015, Vol. 51 Issue 14, p2782-2785, 4p |
| Abstrakt: |
We report a methodology which enables the preparation of dendrimeric contrast agents sensitive to Ca2+ when starting from the monomeric analogue. The Ca-triggered longitudinal relaxivity response of these agents is not compromised by undertaking synthetic transformations, despite structural changes. The in vivo MRI studies in the rat cerebral cortex indicate that diffusion properties of dendrimeric contrast agents have great advantages as compared to their monomeric equivalents. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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