| Autor: |
M. DAMANHURI, I. RASHID, II SHARIFFUDDIN, NG TY, KEVIN WS NG, CHAW SH, NG RT, YOONG BK, LOH PS |
| Předmět: |
|
| Zdroj: |
Medicine & Health (Universiti Kebangsaan Malaysia); 2021 Supplement, Vol. 16, p101-101, 1p |
| Abstrakt: |
Introduction: Living donor liver transplantation (LDLT) has become the gold standard for end stage liver disease. In UMMC, LDLT was started in 2017 for adults and 2019 for paediatrics. Advancements in anaesthetic and surgical techniques have enabled LDLT to be performed safely in young recipients in Malaysia and negate the need to wait for cadaveric liver grafts. Objective: This case series demonstrates the experience in paediatric LDLT in UMMC and highlights the indications, perioperative management and challenges in the development of the program. Methods: A retrospective review of all paediatric liver transplants from 2019 to date was performed through Electronic Medical Records (EMR) followed by a descriptive analysis. Results: UMMC performed 12 cases of paediatric LDLT from the year 2019 to the present with equal numbers in each gender, seven recipients were Malay (58%) and five were Chinese (42%). Seven recipients (58%) were less than two years old at the time of transplantation, whereas the rest were between two to 10 years of age. The mean recipient weight was 13.1 + 6.1kg. Biliary atresia is the primary disease in nine (75%) recipients. The commonest indication for transplantation were post- Kasai patients who developed decompensated liver disease and faltered growth. Other indications included Alagille syndrome, autoimmune sclerosing cholangitis and acute liver failure secondary to viral infection. The mean Paediatric End-stage Liver Disease (PELD) score of the patients was 24.4 + 15.1. The donors were fathers (n=6, 50%), mothers (n=5, 42%) and aunt (n=1, 8%). Two patients passed away post liver transplant, one within 24 hours and another at day 46 post-operatively due to severe sepsis and massive bleeding respectively. Conclusions: In our early experience, paediatric LDLT has made promising strides in Malaysia. Careful patient selection and astute perioperative management determine the immediate and 1-year outcomes of these patients. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
|
